Drug Label Information: Which item refers to genotype-specific dosing?

• A. Drug exposure and clinical response variability
• B. Risk for adverse events
• C. Genotype-specific dosing
• D. Trial design features

Answer: (C)

Genotype-specific dosing means the drug label includes instructions to tailor the dose based on a patient’s genetic makeup. This pharmacogenomic approach helps ensure the medicine works well while minimizing harm because certain genetic variants can change how a person metabolizes or responds to a drug. For example, some genes affect enzyme activity that handles the drug, so the label may require testing or recommend a different dose for specific genotypes. The other options describe general variability in response, risk of side effects, or study design features, none of which specify dosing according to genotype.