Which medications are used to treat drug abuse?

• A. Buprenorphine, Methadone, Naltrexone
• B. Acamprosate, Disulfiram, Naltrexone
• C. Buprenorphine, Disulfiram, Acamprosate
• D. Methadone, Naltrexone, Acamprosate

Answer: (B)

Medications used to treat substance use disorders aim to reduce withdrawal symptoms, curb cravings, or prevent relapse by altering how the body and brain respond to the abused substance. The trio in this option are all approved for alcohol use disorder: acamprosate helps restore the brain’s chemical balance after stopping alcohol and lowers cravings; disulfiram causes unpleasant effects if alcohol is consumed, deterring drinking; and naltrexone blocks opioid receptors and also reduces the rewarding effects of alcohol, helping decrease alcohol use. While methadone or buprenorphine are key treatments for opioid dependence, they are not primarily used to treat alcohol abuse, which is why this set best fits the question.